![]() The joint association between body fat amount and fat distribution with the risk of mortality requires further exploration. Previous studies have also reported the association between WHR and mortality.The mortality risk varies among individuals with the same BF% but different body fat distribution has not been fully characterized. ![]() There is increasing evidence that variation in location of body fat is associated with different risk of cardiovascular disease, diabetes and cancer. In addition, BMI cannot determine the patterns of fat distribution within the body which were identified with other indicators, such as waist-hip ratio (WHR). Furthermore, the optimal cut-off points for the BF% that associated with the lowest mortality risk remain unclear. It is unclear whether the U-shaped pattern of the relationship between fat and mortality persists, when more direct measurement of body fat percentage (BF%), rather than BMI and skinfold thickness, is used. ![]() Some researchers used the skinfold thickness to estimate the body fat,but the skinfold thickness is a measure of subcutaneous fat mass and therefore it is not able to measure intra-abdominal depots. However, BMI cannot discriminate between lean tissue and body fat mass. These findings suggested both underweight and obesity were related with the increased risk of mortality, and the lowest risk of mortality in the whole population was observed with a BMI of around 25 kg/m 2. Recent studies demonstrated the U-shaped association of body mass index (BMI) and all-cause mortality. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Authors confirm that we did not have any special access privileges that others would not have.įunding: This study was funded by the National Health and Medical Research Council (APP1042343), University of Queensland International Scholarship (44078179) and the Excellent Talents Fund Program of Peking University Health Science Center (BMU2017YJ002). They are third party data, and others would be able to access these data in the same manner as the authors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Data are available from the NHANES, Centers for Disease Control and Prevention, USA ( ). Received: MaAccepted: JanuPublished: February 23, 2018Ĭopyright: © 2018 Dong et al. PLoS ONE 13(2):Įditor: Laurie Twells, Memorial University, CANADA (2018) Joint association between body fat and its distribution with all-cause mortality: A data linkage cohort study based on NHANES (1988-2011). Citation: Dong B, Peng Y, Wang Z, Adegbija O, Hu J, Ma J, et al.
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